Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to ...
Read More »Colotan deals with a topic of growing medical and societal concern: obtaining a sufficiently high drug concentration in the colon (large intestine) to efficiently treat diseases of the large intestine. Oral administration of drugs is the most common delivery route due to its non-invasive character and convenience for the patient. However, issues related to pharmacokinetics (PK) and bioavailability remain a prominent cause of oral drug candidate attrition. Therefore, the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) call for research into new predictive (virtual) tools, innovative drug delivery systems and precision medicine approaches. Oral formulations that release the drug in a pH- or time-dependent manner in the colon are commercially available. They are used to obtain topical treatment of colonic diseases such as inflammatory bowel diseases (IBD), that have become a global disease with high incidence in Europe, Oceania and the USA, but also for controlled release of a drug for systemic treatment (e.g. controlled release carvedilol). However, these formulations suffer from an inconsistent and inefficient performance, due to incomplete understanding of processes occurring in the colon. Moreover, the currently available evaluation tools to predict drug performance focus mainly on the upper GI tract, resulting in a lack of validated tools and models of the colon with high physiological relevance and predictive capability
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news
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A new COLOTAN publication on colon absorption and biopharmaceutics modeling
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Epithelial and microbial determinants of colonic drug distribution – a new published article!
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What are the COLOTAN researchers working on?
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COLOTAN researcher Rebekkah Hammar winning the poster award at the 12th Pharmaceutical Profiling in Drug Discovery and Development Symposium
Events
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COLOTAN 4th Symposium – Targeted Drug Delivery in the Gastrointestinal tract
“Targeted Drug Delivery in the Gastrointestinal tract: Current status, emerging techniques and ...
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New Horizons in Drug Delivery and Formulation 2023
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COLOTAN 3rd Symposium
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COLOTAN 3rd Symposium and 4th Network-Wide Event in Parma