This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 956851.

News

A new COLOTAN publication that explores the potential of human intestinal organoids

Exploring the potential of human intestinal organoids: Applications, challenges, and future direction Inês A. Parente, Linda Chiara, Simona Bertoni Published in Life Sciences Abstract The complex and dynamic environment of the gastrointestinal tract shapes one of the fastest renewing tissues in the human body, the intestinal epithelium. Considering the lack of human preclinical studies, reliable models that mimic the intestinal ...

Read More »

A new COLOTAN published article for the better understanding of the luminal conditions in the proximal colon

Characterization of luminal contents from the fasted human proximal colon S. Steigert, J. Brouwers, K. Verbeke, T. Vanuytsel, P. Augustijns In the EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES Abstract To treat colonic diseases more effectively, improved therapies are urgently needed. In this respect, delivering drugs locally to the colon is a key strategy to achieve higher local drug concentrations while minimizing ...

Read More »

Alessia won 2nd place in the “Explore your Entrepreneurial Idea” program!

What an incredible experience it was for Alessia Favaron (COLOTAN ESR9) to develop her business idea in “Explore your Entrepreneurial Idea” program at UCL! She won 2nd place with her HerBioma venture, dedicated to balancing women’s hormonal health with microbiome science. Congratulations to Nidhi Seegobin who was a finalist in the program, and Ieva Karvelyte who won 3rd place!  

Read More »

COLOTAN published an article on the development of a canine artificial colonic mucus model for drug diffusion studies

Development of a canine artificial colonic mucus model for drug diffusion studies V. Barmpatsalou, M. Tjakra, L. Li, I.R. Dubbelboer, E. Karlsson, B. Pedersen Lomstein, C.A.S. Bergström Abstract Colonic mucus is a key factor in the colonic environment because it may affect drug absorption. Due to the similarity of human and canine gastrointestinal physiology, dogs are an established preclinical species ...

Read More »

A review on solidification and oral delivery of biologics to the colon

Solidification and oral delivery of biologics to the colon – A review by COLOTAN researcher Katharina Kopp with the supervision of Lien Saerens (Eurofins), Jody Voorspoels (Eurofins) and Guy Van den Mooter (KU Leuven) that has been published recently in the European Journal of Pharmaceutical Sciences. Abstract The oral delivery of biologics such as therapeutic proteins, peptides and oligonucleotides for ...

Read More »

Pedro Canhão Costa is nominated as best presenter at the 2023 Johnson & Johnson Global Science Symposium

Pedro, COLOTAN Ph.D. Researcher at J&J Johnson Innovative Medicine, participated in the 2023 Johnson & Johnson Global Science Symposium, where Ph.D. and Postdoctoral fellows, from all parts of the world, gathered in Beerse (Belgium), between October 17th and 19th. He was awarded the “Best Outstanding Talk”, amongst all selected Ph.D. and Postdoctoral participants, for his oral presentation titled: “Human organotypic ...

Read More »

Half-time seminar with Marco Tjakra: Artificial colonic mucus for studies of the mucus absorption barrier in vitro

Wednesday 25 October, Marco Tjakra, COLOTAN Early Stage Researcher and PhD student at the Department of Pharmacy and SweDeliver, presented his research on drug dissolution, diffusion and absorption from the human colon with a focus on the role of the colonic mucus layer. It was a hybrid event as one of four half-time seminars organised by the SweDeliver national competence ...

Read More »