This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 956851.

News

Half-time seminar with Marco Tjakra: Artificial colonic mucus for studies of the mucus absorption barrier in vitro

Wednesday 25 October, Marco Tjakra, COLOTAN Early Stage Researcher and PhD student at the Department of Pharmacy and SweDeliver, presented his research on drug dissolution, diffusion and absorption from the human colon with a focus on the role of the colonic mucus layer. It was a hybrid event as one of four half-time seminars organised by the SweDeliver national competence ...

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COLOTAN researcher Theodoros Giakoumis wins Best Online Poster Award at the CoMH Future Research Conference 2023

Theodoros, COLOTAN PhD researcher at UCC, wins the Best Online Poster Award at CoMH Future Research Conference 2023 on his poster entitled “Exploring polysaccharide-based coating for triggering site-specific drug release in the colon: an in vitro and in vivo evaluation”. His research aims to shed light on how the colonic microbiome can be utilized to trigger specific drug release in the ...

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COLOTAN new published article on the challenges and opportunities when managing the clinical effects of drug-induced intestinal dysbiosis

Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to antibiotics: challenges and opportunities L. Gnatzy, G. Ismailos, M. Vertzoni, C. Reppas Abstract The term “intestinal dysbiosis” is used for indicating change(s) of the intestinal microbiota which have been associated with the development of diseases and the deterioration of disease treatments in humans. In this review, documented clinical effects of ...

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A new COLOTAN publication on colon absorption and biopharmaceutics modeling

Physiologically based biopharmaceutics modeling of regional and colon absorption in humans C. Tannergren, H. Jadhav, E. Eckernäs, J. Fagerberg, P. Augustijns, E. Sjögren Abstract Colon absorption is a key determinant for successful development of extended release and colon targeted drug products. This is the first systematic evaluation of the ability to predict in vivo regional differences in absorption and the extent ...

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Epithelial and microbial determinants of colonic drug distribution – a new published article!

Epithelial and microbial determinants of colonic drug distribution Rebekkah Hammar, Mikael E. Sellin, Per Artursson Abstract A dynamic epithelium and a rich microbiota, separated by multi-layered mucus, make up the complex colonic cellular environment. Both cellular systems are characterized by high inter- and intraindividual differences, but their impact on drug distribution and efficacy remains incompletely understood. This research gap is ...

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What are the COLOTAN researchers working on?

What is the colon? How do we get the drugs in the colon? And many other questions are answered in this short video explaining what the COLOTAN researchers are working on.. With special thanks to Katharina Kopp (ESR4 in COLOTAN), who made this video happen!

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COLOTAN researcher Rebekkah Hammar winning the poster award at the 12th Pharmaceutical Profiling in Drug Discovery and Development Symposium

Rebekkah Hammar won the poster award at the 12th Pharmaceutical Profiling in Drug Discovery and Development Symposium in Uppsala. Poster titled: 3D COLONOIDS AS INTESTINAL IN VITRO ADME MODELS REFLECTIVE OF NATIVE EPITHELIUM. You may also check out Rebekkah’s work in this new publication in the Journal of Neuroscience, entitled “Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, ...

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New published article on colonic drug delivery

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics L. E. McCoubrey, A. Favaron, A. Awad, M. Orlu, S. Gaisford, A. W. Basit, Abstract Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to the colon requires considered formulation development, as both oral and ...

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Congratulations to COLOTAN colleagues, Prof. Mullertz and Prof. Rades, for being selected as 2022 AAPS Fellows!

We are very happy that Professor Anette Mullertz and Professor Thomas Rades have been made 2022 AAPS Fellows! Each year, the American Association of Pharmaceutical Scientists (AAPS)  Fellows Committee recommends a few members as Fellows in recognition of their professional excellence and sustained superior impact in fields relevant to the AAPS mission, “to advance the capacity of pharmaceutical scientists to develop products and ...

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COLOTAN 3rd Symposium and 4th Network-Wide Event in Parma

A COLOTAN week in Parma, Italy! The 4th COLOTAN Network-wide event was held in Parma, Italy during the week of 23rd January, 2023. During the first two days, the 13 Early-Stage Researchers (ESRs) followed several dedicated trainings. Sessions were provided on in vitro and in vivo models of inflammatory bowel diseases (IBD), and pathophysiology of IBD. To enhance their soft ...

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