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Physiologically based biopharmaceutics modeling of regional and colon absorption in humans C. Tannergren, H. Jadhav, E. Eckernäs, J. Fagerberg, P. Augustijns, E. Sjögren Abstract Colon absorption is a key determinant for successful development of extended release and colon targeted drug products. This is the first systematic evaluation of the ability to predict in vivo regional differences in absorption and the extent ...

Epithelial and microbial determinants of colonic drug distribution Rebekkah Hammar, Mikael E. Sellin, Per Artursson Abstract A dynamic epithelium and a rich microbiota, separated by multi-layered mucus, make up the complex colonic cellular environment. Both cellular systems are characterized by high inter- and intraindividual differences, but their impact on drug distribution and efficacy remains incompletely understood. This research gap is ...

What is the colon? How do we get the drugs in the colon? And many other questions are answered in this short video explaining what the COLOTAN researchers are working on.. With special thanks to Katharina Kopp (ESR4 in COLOTAN), who made this video happen!

Rebekkah Hammar won the poster award at the 12th Pharmaceutical Profiling in Drug Discovery and Development Symposium in Uppsala. Poster titled: 3D COLONOIDS AS INTESTINAL IN VITRO ADME MODELS REFLECTIVE OF NATIVE EPITHELIUM. You may also check out Rebekkah’s work in this new publication in the Journal of Neuroscience, entitled “Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, ...

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics L. E. McCoubrey, A. Favaron, A. Awad, M. Orlu, S. Gaisford, A. W. Basit, Abstract Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to the colon requires considered formulation development, as both oral and ...

We are very happy that Professor Anette Mullertz and Professor Thomas Rades have been made 2022 AAPS Fellows! Each year, the American Association of Pharmaceutical Scientists (AAPS)  Fellows Committee recommends a few members as Fellows in recognition of their professional excellence and sustained superior impact in fields relevant to the AAPS mission, “to advance the capacity of pharmaceutical scientists to develop products and ...

A COLOTAN week in Parma, Italy! The 4th COLOTAN Network-wide event was held in Parma, Italy during the week of 23rd January, 2023. During the first two days, the 13 Early-Stage Researchers (ESRs) followed several dedicated trainings. Sessions were provided on in vitro and in vivo models of inflammatory bowel diseases (IBD), and pathophysiology of IBD. To enhance their soft ...

COLOTAN 3rd Network-Wide Event was held in Leuven, Belgium, from 8th – 10th June 2022. We had the first COLOTAN event where the whole team of ESRs and supervisors met together, since the project kicked off during COVID19 measures. The first 2 days (Wednesday 8th & Thursday 9th June) were filled with dedicated training sessions (scientific and soft skills), including visits ...

The Harrison Memorial Medal is awarded every two years, in memory of the distinguished pharmaceutical chemist Colonel EF Harrison. It is presented to an individual who has made an outstanding contribution in advancing pharmaceutical science. Professor Basit is internationally recognised for leading in the fields of oral drug delivery, microbiome medicines, three-dimensional printing of pharmaceuticals and digital health. He has ...

1 PhD position in the EU Horizon 2020 project COLOTAN