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Exploring the potential of human intestinal organoids: Applications, challenges, and future direction Inês A. Parente, Linda Chiara, Simona Bertoni Published in Life Sciences Abstract The complex and dynamic environment of the gastrointestinal tract shapes one of the fastest renewing tissues in the human body, the intestinal epithelium. Considering the lack of human preclinical studies, reliable models that mimic the intestinal ...

Characterization of luminal contents from the fasted human proximal colon S. Steigert, J. Brouwers, K. Verbeke, T. Vanuytsel, P. Augustijns In the EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES Abstract To treat colonic diseases more effectively, improved therapies are urgently needed. In this respect, delivering drugs locally to the colon is a key strategy to achieve higher local drug concentrations while minimizing ...

Alessia is delighted to have won the best lecture (runner-up) award at the SoP Research Day and expresses that the best part was sharing the achievement with her great friend Nidhi Seegobin: “There is never a moment when we stop encouraging each other to aim for the best in ourselves and our work, and this was another wonderful proof of ...

What an incredible experience it was for Alessia Favaron (COLOTAN ESR9) to develop her business idea in “Explore your Entrepreneurial Idea” program at UCL! She won 2nd place with her HerBioma venture, dedicated to balancing women’s hormonal health with microbiome science. Congratulations to Nidhi Seegobin who was a finalist in the program, and Ieva Karvelyte who won 3rd place!  

Development of a canine artificial colonic mucus model for drug diffusion studies V. Barmpatsalou, M. Tjakra, L. Li, I.R. Dubbelboer, E. Karlsson, B. Pedersen Lomstein, C.A.S. Bergström Abstract Colonic mucus is a key factor in the colonic environment because it may affect drug absorption. Due to the similarity of human and canine gastrointestinal physiology, dogs are an established preclinical species ...

Solidification and oral delivery of biologics to the colon – A review by COLOTAN researcher Katharina Kopp with the supervision of Lien Saerens (Eurofins), Jody Voorspoels (Eurofins) and Guy Van den Mooter (KU Leuven) that has been published recently in the European Journal of Pharmaceutical Sciences. Abstract The oral delivery of biologics such as therapeutic proteins, peptides and oligonucleotides for ...

Pedro, COLOTAN Ph.D. Researcher at J&J Johnson Innovative Medicine, participated in the 2023 Johnson & Johnson Global Science Symposium, where Ph.D. and Postdoctoral fellows, from all parts of the world, gathered in Beerse (Belgium), between October 17th and 19th. He was awarded the “Best Outstanding Talk”, amongst all selected Ph.D. and Postdoctoral participants, for his oral presentation titled: “Human organotypic ...

Sydney Mwasambu, COLOTAN Early Stage Researcher and PhD student at Uppsala University in Prof. Daniel Globisch’s group, shared their recent developments of their chemoselective probe technology at the 3rd Nordic Metabolomics Society conference.

“Some individuals possess incredible potential – and the ability to harness it. One such person I greatly admire is Christel Bergström Christel is a professor, successful researcher, program director, collaborative dean, and entrepreneur – to mention a few of her professional roles. No matter how much she takes on, I am delighted that she is generous with her time when I ...

Wednesday 25 October, Marco Tjakra, COLOTAN Early Stage Researcher and PhD student at the Department of Pharmacy and SweDeliver, presented his research on drug dissolution, diffusion and absorption from the human colon with a focus on the role of the colonic mucus layer. It was a hybrid event as one of four half-time seminars organised by the SweDeliver national competence ...